Cayenne may increase the risk of bleeding or potentiate the effects of warfarin therapy.
- Am J Health Syst Pharm 2000 Jul 1;57(13):1221-7; quiz 1228-30 -- Potential interactions between alternative therapies and warfarin. -- Heck AM, DeWitt BA, Lukes AL. -- School of Pharmacy and Pharmacal Sciences, Purdue University, Indianapolis, IN, USA.

Around one third of patients may experienced local adverse events with capsaicin as a topical treatment for pain.

Cayenne can increase the amount of absorption rate of other herbs and prescription medications due to its' heating properties.

Results show that Capsicum ingestion reduces oral drug bioavailability, likely as a result of the gastrointestinal effects of capsaicin.
- Can J Physiol Pharmacol 1999 Jun;77(6):441-6 -- Ingestion of chilli pepper (Capsicum annuum) reduces salicylate bioavailability after oral asprin administration in the rat. -- Cruz L, Castaneda-Hernandez G, Navarrete A.

It was found that a single dose of Capsicum fruit could affect pharmacokinetic parameters of theophylline, while a repeated dose affected the metabolic pathway of xanthine oxidase.
- Eur J Drug Metab Pharmacokinet 1995 Jul-Sep;20(3):173-8 -- Theophylline pharmacokinetics and metabolism in rabbits following single and repeated administration of Capsicum fruit. -- Bouraoui A, Brazier JL, Zouaghi H, Rousseau M.

Use extreme caution around children when using cayenne and capsaicin products. Recommendations have been found on the internet to use cayenne as a deterrent to thumb sucking -- please do not follow those questionable instructions. Learn more about Cayenne.

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