Nonsteroidal anti-inflammatory drugs may negate the usefulness of feverfew in the treatment of migraine headaches.
- Arch Intern Med 1998 Nov 9;158(20):2200-11 -- Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. -- Miller LG.

Pregnant women should not use the herb, it may stimulate uterine contractions.

Fresh leaves may cause mouth ulcers, abdominal pain, or experience loss of taste. If these symptoms develop, discontinue use and notify your doctor.

Feverfew may interfere with the blood's clotting ability; talk to your doctor before using if you have a clotting disorder or take anticoagulant medicine.

You may need to take feverfew daily for two to three months before it has any effect.

Feverfew may increase the risk of bleeding or potentiate the effects of warfarin therapy.
- Am J Health Syst Pharm 2000 Jul 1;57(13):1221-7; quiz 1228-30 -- Potential interactions between alternative therapies and warfarin. -- Heck AM, DeWitt BA, Lukes AL.

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