Goldenseal Side Effects & Warnings

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Goldenseal is a potent plant and must be used with care.

Do not take on a daily basis for more than a week at a time.

Eating the fresh plant can cause inflammation of the mucous tissue

In high doses, goldenseal can irritate the skin, mouth, throat, and vagina. If any of these develop, stop taking immediately.

It may cause nausea and diarrhea. If any of these develop, stop taking immediately.

Do not use during pregnancy; it may stimulate the uterus.

Do not use goldenseal without consulting a physician if you have had heart disease, diabetes, glaucoma, a stroke, or high blood pressure. It stimulates the heart muscle, and the result is increased blood pressure.

Do not give goldenseal to children under two. Start with small doses for older children and adults

High doses may interfere with vitamin B metabolism.

Golden Seal should not be used by individuals with hypoglycemia.

The main alkaloid constituent of Goldenseal is berberine. The topical application of Goldenseal or berberine to the skin or eyes raises the possibility that an adverse phototoxic reaction may result from an interaction between the alkaloid and light.

These findings suggest that exposure to sunlight or artificial light sources emitting UVA should be avoided when topical preparations derived from Goldenseal or containing berberine are used.
- Chem Res Toxicol 2001 Nov;14(11):1529-34 -- Photochemistry and photocytotoxicity of alkaloids from Goldenseal (Hydrastis canadensis L.) 1. Berberine. -- Inbaraj JJ, Kukielczak BM, Bilski P, Sandvik SL, Chignell CF.

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