Consult a doctor or an herbalist before using St.-John's-wort.
If you are pregnant or lactating or taking any other anti-depressants like
Prozac, check with your physician before taking St. John's wort.
It is not effective for severe depression, and no one should stop taking any
prescribed medications for depression without proper medical care.
High blood pressure, headaches, stiff neck, nausea, and vomiting. In the
fair-skinned, it can exacerbate sunburn and cause blistering after sun
Avoid the following substances when using St.-John's-wort: Amino acids
tryptophan and tyrosine; amphetamines; asthma inhalants; beer, coffee, wine;
chocolate, fava beans, salami, smoked or pickled foods, and yogurt; cold or hay
fever medicines; diet pills; narcotics; nasal decongestants. They all contain
chemicals that react adversely to hypericin, causing high blood pressure and
Avoid exposure to the sun during treatment, it can cause heightened sun
sensitivity when taken in large amounts. Anyone who is hypersensitive to
sunlight or is taking other photosensitizing drugs should be cautious.
Interferes with the absorption of iron and other minerals
St. John's wort should not be taken with any other antidepressants
St. John's wort should be taken with meals
Hypericum preparations must not be taken at the same time as other
If co-medication with coumarin-type anticoagulants is unavoidable, it must only
be undertaken provided the physician closely monitors clotting parameters.
Co-medication with ciclosporin and indinavir, and for the time being, other
protease inhibitors used in anti-HIV treatment, is absolutely contraindicated.
In transplant patients, self-medication with St John's wort (Hypericum
perforatum) has led to a drop in plasma levels of the immuno suppressant drug
cyclosporine, causing tissue rejection.
Because the majority of people who take this popular over-the-counter
preparation do so without formal psychiatric evaluations, risk of hypericum-induced
mania may be significant. Physicians should screen patients for a history of
hypomania or mania before recommending use of St. John's wort.
St John's wort may cause serotonin syndrome in sensitive patients. In addition,
St John's wort may be associated with hair loss. For clinical reasons, it is
important to recognize and report adverse reactions to herbal remedies and to
document that these treatments have side effects commensurate with their potent
action on brain neurochemistry.
Results support the notion that hyperforin interferes with the storage of
monoamines in synaptic vesicles.
Because of the potential for side-effects and drug interactions it is important
for anaesthetists to be aware of use.
A number of clinically significant interactions have been identified with
prescribed medicines including warfarin, phenprocoumon, cyclosporin, HIV
protease inhibitors, theophylline, digoxin and oral contraceptives resulting in
a decrease in concentration or effect of the medicines.
pharmacodynamic interactions with selective serotonin re-uptake inhibitors and
serotonin receptor-agonists such as triptans used to treat migraine were
identified. These interactions are associated with an increased risk of adverse
St. John's Wort contains photosensitizing substances, which, at high dose, or
during chronic use, may provoke intense dermatitis or photosensitivity. The
potential occurrence of side effects with its use has led the European Agency
for drug assessment and the French Medicines Agency to decree that all
magistral preparations containing St. John's wort must be labeled:
"Warning, risk of drug interactions".
St. John's wort extract has a clear inhibitory effect on the neuronal uptake
not only of serotonin, noradrenaline, and dopamine but also of gamma-aminobutyric
acid (GABA) and L-glutamate.
St. John's wort has the potential to alter medication pharmacokinetics and the
St John's wort enormously decreases the plasma concentrations of omeprazole.
ST. JOHN'S WORT - IN STOCK
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