Valerian and lorazepam may cause an adverse interaction.
- Drugs Aging 2002;19(11):879-86 -- Potential Interactions between Herbal Medicines and Conventional Drug Therapies Used by Older Adults Attending a Memory Clinic. -- Dergal JM, Gold JL, Laxer DA, Lee MS, Binns MA, Lanctot KL, Freedman M, Rochon PA.

Valerian may potentiate the effects of antiepileptic medications, increasing their sedative and cognitive effects.
- 2001 Dec;2(6):524-532 -- Herbal Medicines and Epilepsy: The Potential for Benefit and Adverse Effects. -- Spinella M.

Valerian should not be used concomitantly with barbiturates because excessive sedation may occur.
- Arch Intern Med 1998 Nov 9;158(20):2200-11 -- Herbal medicinals: selected clinical considerations focusing on known or potential drug-herb interactions. -- Miller LG.

May produce sensations of "strangeness" in some individuals. These persons should not use valerian.

In extremely high doses, valerian may cause paralysis and weakening of the heartbeat. Do not exceed the recommended dose.

The concomitant use of opioid analgesics with the sedative herbal supplements, valerian, kava and chamomile, may lead to increased central nervous system (CNS) depression.
- J Clin Pharm Ther 2002 Dec;27(6):391-401 -- Herbal medication: potential for adverse interactions with analgesic drugs. -- Abebe W.

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